Finally, complexes 5 and 6 significantly reduced the production of pyocyanin, a virulence factor in Pseudomonas aeruginosa controlled by quorum sensing, and increased cell survival after exposure to this bacterium. Gold( III) complexes 1–3 significantly reduced the amount of ergosterol in the cell membrane of Candida albicans at the subinhibitory concentration of 0.5 × MIC (minimal inhibitory concentration), while the corresponding imidazole ligands did not significantly affect the ergosterol content, indicating that the mechanism of action of the gold( III)–azole complexes is associated with inhibition of ergosterol biosynthesis. The complexes 4–7 and the corresponding antifungal azoles inhibited the growth of dermatophyte Microsporum canis at 50 and 25 μg mL −1. Moreover, gold( III) complexes 4–7 with clinically used antifungal agents clotrimazole, econazole, tioconazole and voriconazole, respectively, have, in most cases, enhanced antimicrobial effectiveness relative to the corresponding azoles, with the best improvement achieved after complexation of tioconazole ( 6) and voriconazole ( 7). In vitro antimicrobial assays showed that the complexation of inactive azoles, imidazole, 1-isopropylimidazole and 1-phenylimidazole, to the Au( III) ion led to complexes 1–3, respectively, with moderate activity against the investigated strains and low cytotoxicity on the human normal lung fibroblast cell line (MRC-5).
In all complexes, the corresponding azole ligand is monodentately coordinated to the Au( III) via the imidazole or triazole nitrogen atom, while the remaining coordination sites are occupied by chloride anions leading to the square-planar arrangement. E-mail: a search for novel antimicrobial metal-based therapeutic agents, mononuclear gold( III) complexes 1–7 of the general formula, where azole stands for imidazole (im, 1), 1-isopropylimidazole (ipim, 2), 1-phenylimidazole (phim, 3), clotrimazole (ctz, 4), econazole (ecz, 5), tioconazole (tcz, 6) and voriconazole (vcz, 7) were synthesized, characterized and biologically evaluated. Dr Zorana Đinđića 81, 18108 Niš, Serbia e Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia. E-mail: d University of Niš, Faculty of Medicine, Department of Chemistry, Blvd. E-mail: c Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia.
E-mail: b Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000, Ljubljana, Slovenia. * a a University of Kragujevac, Faculty of Science, Department of Chemistry, R. Technical Sales Manager Louise L'Homme said: "evenTech Ireland has proven itself as a pivotal information and networking event within Ireland's installation technology and entertainment lighting sectors and, as such, is the ideal forum for us to showcase directly what Artistic Licence has to offer.Ī top manufacturer of lighting control systems, Artistic Licence, will be exhibiting at evenTech Ireland for the first time this November.Īrtistic Licence's presence at the show comes as a result of its growing customer base in Ireland and the increased demand for Artistic Licence products and expertise in Ireland's expanding architectural and entertainment lighting market.Dalton Trans., 2022, 51, 5322-5334 Clinically used antifungal azoles as ligands for gold( III) complexes: the influence of the Au( III) ion on the antimicrobial activity of the complex † "Not only do we want to be on hand to meet with our existing customers and project managers, but we want to be able to present and explain the technology within our product range to those who are new to Artistic Licence. We can show our customers how to maximise the potential of an entire project using well-planned control systems." We find that projects often concetrate on the visual and audio aspects and give the control and integration aspects a lower priority. On the stand will be a selection of DMX and DALI control tools including the newly released Sign-Control - a DMX512 playback system aimed at simple to sophisticated room control applications which includes 24 memories and six sequences and Two-Play - a two-universe, multiple record and playback Art-Net controller which provides the perfect control solution for small to medium-size installations. Two-Play was recently given Commended status by the judges of PLASA09 Awards for Innovation.įurther new Artistic Licence releases will also be put through their paces.